ProfessorClinton Bruce
Associate Head of School, Research
Faculty of Health/School of Exercise and Nutrition Sciences/Institute for Physical Activity and Nutrition
Orcid identifier0000-0002-0515-3343 (opens in a new tab)
- Associate Head of School, ResearchFaculty of Health/School of Exercise and Nutrition Sciences/Institute for Physical Activity and Nutrition
- +61 3 924 46684 (Work)
- Melbourne Burwood Campus, 221 Burwood Highway, Burwood, Victoria 3125
RESEARCH INTERESTS
Dr Bruce's research is focussed on understanding the regulation of glucose
metabolism in skeletal muscle and liver in health and disease. He is
particularly interested in identifying mechanisms underlying the development
of glucose intolerance and insulin resistance. He also has an interest in
identifying the role of lipids in regulating skeletal muscle function. His
research involves the use of stable isotope methodology and GC-MS based
metabolomics to measure glucose and lipid fluxes, protein synthesis and
mitochondrial biogenesis.
Knowledge Areas
Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes,
metabolomics, stable isotopes, muscle physiology
Projects
Mechanisms of glucose intolerance and insulin resistance.
The role of membrane lipids in regulating skeletal muscle physiology.
metabolism in skeletal muscle and liver in health and disease. He is
particularly interested in identifying mechanisms underlying the development
of glucose intolerance and insulin resistance. He also has an interest in
identifying the role of lipids in regulating skeletal muscle function. His
research involves the use of stable isotope methodology and GC-MS based
metabolomics to measure glucose and lipid fluxes, protein synthesis and
mitochondrial biogenesis.
Knowledge Areas
Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes,
metabolomics, stable isotopes, muscle physiology
Projects
Mechanisms of glucose intolerance and insulin resistance.
The role of membrane lipids in regulating skeletal muscle physiology.
GRANTS
- GRANTMatrix Matters: The Role of Intrinsic Beef Fat in Modulating Postprandial Muscle Protein Synthesis in Humans1 Apr 2026 - 31 Mar 2028People funded by this grant:
- Hamilton L,
- Kowalski G,
- Urwin C,
- Huschtscha Z,
- Bruce C
- GRANTALMOND ProFIT-PM Almond protein powder to enhance fitness training adaptations in postmenopausal women.6 May 2024 - 19 Dec 2025People funded by this grant:
- GRANTProtein intervention to minimize exercise-induced hypoglycemia in people with type 1 diabetes1 Nov 2023 - 31 Oct 2026People funded by this grant:
- Morrison D,
- Kowalski G,
- Bruce C,
- Dao G
- GRANTInvestigating the role of neurturin as a therapeutic strategy to delay ALS disease progression1 Jan 2023 - 31 Dec 2023People funded by this grant:
- Russell A,
- Ruas J,
- Bruce C,
- Gatta PD,
- Lindsay A
- GRANTCan dietary supplementation with Krill-Oil improve ME/CFS symptoms?4 Apr 2022 - 3 Apr 2025People funded by this grant:
- GRANTA novel liquid biopsy approach to study in vivo -cell insulin synthesis in humans1 Jan 2022 - 31 Dec 2022People funded by this grant:
- Kowalski G,
- Bruce C,
- Shaw C
- GRANTDeciphering the mechanisms of prostprandial glucose disposal1 Jan 2022 - 30 Sep 2023People funded by this grant:
- Shaw C,
- Bruce C,
- Kowalski G,
- Howlett K
- GRANTFasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance1 Jun 2021 - 31 May 2022People funded by this grant:
- Shaw C,
- Bruce C,
- Howlett K,
- Mcgee S,
- Kowalski G
- GRANTFasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance1 Jun 2021 - 31 May 2022People funded by this grant:
- Shaw C,
- Bruce C,
- Howlett K,
- McGee S,
- Kowalski G
- GRANTAminogenic insulin-glucagon secretion and action in human insulin resistance1 Jan 2020 - 28 Feb 2022People funded by this grant:
- Kowalski G,
- Bruce C
- GRANTMechanisms of insulin resistance in humans1 Jan 2019 - 31 Dec 2019People funded by this grant:
- Bruce C,
- Kowalski G
- GRANTMetabolic tug-of-war: deciphering the role of glucagon and insulin under physiologically relevant conditions in humans1 Jan 2019 - 31 Dec 2019People funded by this grant:
- Kowalski G,
- Bruce C
- FELLOWSHIPDefining a novel pathway in the regulation of skeletal muscle mass4 Jan 2017 - 3 Jan 2021People funded by this grant:
- Clinton Bruce
- GRANTThe role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes1 Jan 2017 - 31 Dec 2019People funded by this grant:
- McGee S,
- Bruce C,
- White F,
- Walder K
- GRANTThe role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy1 Jan 2017 - 31 Dec 2017People funded by this grant:
- Mcgee S,
- Bruce C
- GRANTLiver-type pyruvate kinase: a novel anti-hyperglycemic target1 Jan 2016 - 31 Dec 2016People funded by this grant:
- Kowalski G,
- Bruce C
- CONTRACT RESEARCHMeasurement of plasma free fatty acids3 Dec 2015 - 2 Dec 2016People funded by this grant:
- Bruce C,
- Kowalski G
- CONTRACT RESEARCHDetermination of 6,6-2H glucose enrichment in plasma25 Aug 2015 - 3 Sep 2015People funded by this grant:
- Bruce C,
- Kowalski G
- GRANTDoes mitochondrial dysfunction impair muscle glucose metabolism?1 Jan 2015 - 31 Dec 2015People funded by this grant:
- Bruce C,
- Kowalski G,
- Kaur G
- GRANTTargeting hepatic energy expenditure to improve glycaemic control1 Jan 2015 - 31 Dec 2015People funded by this grant:
- Kowalski G,
- Bruce C
- GRANTUnderstanding the mechanisms of diet-induced defects in hepatic glucose metabolism.1 Jan 2014 - 31 Dec 2014People funded by this grant:
- Clinton Bruce
- GRANTSphingosine kinase: a target for obesity-induced insulin resistance6 Feb 2012 - 31 Dec 2014People funded by this grant:
- Bruce C,
- Lee-Young R
- GRANTActivation of HSP72 in skeletal muscle as a therapeutic target for obesity1 Jan 2011 - 31 Dec 2013People funded by this grant:
- Febbraio M,
- Bruce C,
- Mcgee S,
- Hargreaves M