ProfessorAaron Russell
Honorary Professor
Faculty of Health/School of Exercise and Nutrition Sciences/Institute for Physical Activity and Nutrition
Orcid identifier0000-0002-7323-9501 (opens in a new tab)
- Honorary ProfessorFaculty of Health/School of Exercise and Nutrition Sciences/Institute for Physical Activity and Nutrition
RESEARCH INTERESTS
My research group is focused on determining the molecular factors that control
skeletal muscle wasting, growth and regeneration. Investigations are performed
in humans using in vivo models of muscle wasting including motor neuron
disease (MND), muscular dystrophy (DMD and sarcopenia. Acute and chronic
exercise protocols are used as models to investigate the signalling proteins
that regulate skeletal muscle growth and regeneration.
* In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.
* In vivo rodent models are used to investigate the role of specific molecular targets using AAV and lentiviral technology.
* Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays.
* Molecular targets of interest include PGC-1, STARS and several miRNA species.
skeletal muscle wasting, growth and regeneration. Investigations are performed
in humans using in vivo models of muscle wasting including motor neuron
disease (MND), muscular dystrophy (DMD and sarcopenia. Acute and chronic
exercise protocols are used as models to investigate the signalling proteins
that regulate skeletal muscle growth and regeneration.
* In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.
* In vivo rodent models are used to investigate the role of specific molecular targets using AAV and lentiviral technology.
* Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays.
* Molecular targets of interest include PGC-1, STARS and several miRNA species.
GRANTS
- GRANTLooking Beyond the Brain: How Motor Neuron Disease Impacts the Heart1 Jul 2026 - 30 Jun 2027People funded by this grant:
- Bernardo B,
- Russell A
- GRANTNew viral-mediated TDP-43 mouse models of MND3 Oct 2023 - 2 Oct 2026People funded by this grant:
- Walker A,
- Morsch M,
- Brown-Wright H,
- Lisowski L,
- Russell A
- GRANTInvestigating the role of neurturin as a therapeutic strategy to delay ALS disease progression1 Jan 2023 - 31 Dec 2023People funded by this grant:
- Russell A,
- Ruas J,
- Bruce C,
- Gatta PD,
- Lindsay A
- GRANTEvaluation of a novel inducible muscle-specific TDP-43 mouse model of ALS1 Oct 2022 - 30 Sep 2024People funded by this grant:
- Russell A,
- Walker A,
- Wright D
- GRANTIdentifying biomarkers from extracellular vesicles for early detection, disease progression and therapeutic efficiency in MND1 Dec 2020 - 30 Nov 2022People funded by this grant:
- Russell A,
- Walker A,
- Mathivanan S,
- Chung R
- GRANTPromoting axon regeneration by suppressing miRNA-23a8 Nov 2018 - 30 Apr 2021People funded by this grant:
- Islam R,
- Russell A,
- Foletta T,
- Gatta PD,
- Romero FG
- GRANTUtilising a novel research model of motor neurone disease to investigate potential new therapeutic strategies: a proof-of-concept study5 Mar 2018 - 28 Mar 2019People funded by this grant:
- Russell A,
- Foletta T,
- Gatta PD,
- Islam R
- GRANTRescuing the STARS protein as a treatment for muscular dystrophy15 Jul 2014 - 31 Dec 2015People funded by this grant:
- Russell A,
- Lynch G,
- Gatta PD
- GRANTInhibiting microRNA-23 as a therapeutic strategy to treat amyotrophic lateral sclerosis (ALS)1 Jan 2014 - 31 Dec 2014People funded by this grant:
- Russell A,
- Chung R
- GRANTRegulation of post-exercise recovery: Understanding the mechanisms of muscle inflammation and repair20 Nov 2013 - 19 Nov 2014People funded by this grant:
- Vella L,
- Russell A,
- Snow R
- INFRASTRUCTUREExercise Open Treadmill with Shock for Rats and Mice. C-Pace Cell Culture EP stimulator with EHV100.1 Jan 2013 - 30 Jun 2014People funded by this grant:
- Aaron Russell
- GRANTRole of STARS signalling in maintaining skeletal muscle mass and function; implications for our ageing population1 Jan 2013 - 31 Dec 2015People funded by this grant:
- Russell A,
- Lynch G
- GRANTSkeletal muscle CD34+cells as targets to increase energy expenditure and insulin1 Jan 2011 - 15 Aug 2012People funded by this grant:
- Aaron Russell
- GRANTHealth benefits of long-term strength training in patients with chronic kidney disease.30 Jun 2009 - 30 Jun 2011People funded by this grant:
- Petersen A,
- McMahon L,
- Russell A,
- Ducher G
- GRANTThe role of Notch signalling in muscular dystrophy15 Jun 2009 - 31 Dec 2011People funded by this grant:
- Lynch G,
- Russell A
- GRANTPhysiological effects on volunteer fire fighters during fire supression of Australian bushfires2 Sep 2008 - 31 Dec 2008People funded by this grant:
- Russell A,
- Phillips M
- FELLOWSHIPMolecular targets involved with human muscle atrophy and hypertrophy31 Mar 2008 - 31 Mar 2012People funded by this grant:
- Aaron Russell
- GRANTDermatan sulphate as a nutraceutical for application in the field of muscle growth: the effect of dermatan sulphate on human muscle cells27 Nov 2007 - 20 Mar 2009People funded by this grant:
- Cameron-Smith D,
- Crowe T,
- Russell A
- GRANTUnderstanding human muscle wasting15 Oct 2007 - 16 Oct 2008People funded by this grant:
- Aaron Russell
- GRANTMolecular mechanisms regulating mitochondrial development and function in the skeletal muscle of ALS patients.1 Jun 2006 - 30 Jun 2007People funded by this grant:
- Aaron Russell