ProfessorKen Walder

Chair In Metabolic Diseases

Faculty of Health/School of Medicine/Institute for Mental and Physical Health and Clinical Translation

  • Chair In Metabolic Diseases
    Faculty of Health/School of Medicine/Institute for Mental and Physical Health and Clinical Translation
  • +61 3 522 72883 (Work)
  • Geelong Waurn Ponds Campus, 75 Pigdons Road, Waurn Ponds, Victoria 3216

RESEARCH INTERESTS

Professor Walder's research is primarily focused on the discovery and
validation of novel drug treatments for complex diseases. This research
utilises state of the art equipment and technologies, in combination with
unique model systems and sample collections, to screen for small molecules
that can be used to treat complex diseases. The novel drug candidates are
tested in in vitro and in vivo model systems to establish their potential for
development as therapeutics.

Professor Walder works closely with the clinical research team at IMPACT,
based at University Hospital Geelong, and has a strong focus on translating
basic research findings into the clinical research program, with the
overarching aim of improving the lives of people with mental health disorders.

Knowledge Areas
Mental health (major depressive disorder, bipolar disorder, schizophrenia).

Metabolic diseases (obesity, type 2 diabetes, non-alcoholic fatty liver
disease).

Genetics.

Drug discovery.

Projects
See current School of Medicine Honours/PhD project booklet.

Current projects include:

Repurposing drugs to treat myalgic encephalomyelitis/chronic fatigue syndrome

Repurposing drugs to treat bipolar disorder

Novel microRNAs involved in the pathophysiology
and treatment of bipolar disorder

Alternative approaches in the treatment of bipolar disorder

Exploration of potential novel therapies for affective disorders

GRANTS

  • CONTRACT RESEARCH
    Google - Elucidating Bioenergetic Resilience and Ion Homeostasis in Bipolar Disorder: A Stepping Stone to Novel Therapies
    28 Oct 2025 - 28 Oct 2026
    People funded by this grant:
    • Ken Walder
    Google Asia Pacific - $150,240.38
  • GRANT
    SYNDICAT: Synergy for the Development of Innovative Clinical Treatments in Schizophrenia
    1 Jan 2025 - 31 Dec 2029
    People funded by this grant:
    NHMRC Synergy Grants - 2035912 - $5,000,000.00
  • GRANT
    Biomarkers of negative symptoms, cognitive impairment and metabolic abnormalities in schizophrenia
    1 Oct 2022 - 1 Apr 2024
    People funded by this grant:
    Royal Australian and New Zealand College of Psychiatrists Foundation Catalyst Grants - $4,980.00
  • GRANT
    The miRNA-mRNA integration of GenieUs multi-omics aberration platform for amyotrophic lateral sclerosis.
    11 Jul 2022 - 9 Dec 2022
    People funded by this grant:
    • Walder K,
    • Truong TTT
    International Education Resilience Fund - $15,000.00
  • GRANT
    Drug discovery for schizophrenia using patient-derived stem cells
    1 Jun 2022 - 30 Sep 2025
    People funded by this grant:
    MRFF (NHMRC) - SCTM Stem Cell Therapies Grant - 2017861 - $203,999.00
  • GRANT
    TIDE: Trimetazidine in bipolar depression
    17 May 2022 - 17 May 2025
    People funded by this grant:
    SMRI - Treatment Trials - Stanley Medical Research Institute - #21T-005 - $2,155,842.43
  • GRANT
    Can dietary supplementation with Krill-Oil improve ME/CFS symptoms?
    4 Apr 2022 - 3 Apr 2025
    People funded by this grant:
    Equity Trustees - The Mason Foundation National Medical Program - MASONMECFS054 - $285,000.00
  • GRANT
    Repurposing drugs to treat bipolar depression using stem cell technology
    3 Dec 2021 - 3 Dec 2022
    People funded by this grant:
    Milken Institute and Baszucki Brain Research Fund - Bipoloar Disorder Grant - $269,566.99
  • GRANT
    Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS
    1 Nov 2020 - 31 Oct 2025
    People funded by this grant:
    NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity - APP1199363 - $1,083,010.00
  • GRANT
    CREDIT: The CRE for the Development of Innovative Therapies for Psychiatric Disorders
    1 Jan 2019 - 31 Dec 2023
    People funded by this grant:
    • Berk M,
    • McGrath J,
    • McGorry P,
    • McNeil J,
    • Malhi G
    NHMRC - Centres of Research Excellence - APP1153607 - $2,534,614.86
  • GRANT
    Beak and Feather Disease Virus in wild psittacine populations in Australia
    26 Sep 2017 - 31 Dec 2017
    People funded by this grant:
    • Bennett A,
    • Berg M,
    • Walder K,
    • Martens JHM
    Ecological Society Australia - Student Research Award - $1,500.00
  • GRANT
    The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes
    1 Jan 2017 - 31 Dec 2019
    People funded by this grant:
    NHMRC Project Grant - APP1127059 - $655,473.45
  • INFRASTRUCTURE
    NHMRC Equipment Grant 2016
    15 Nov 2016 - 30 Jun 2017
    People funded by this grant:
    NHMRC - Equipment Grant (pre 2017) - GNT9000413 - $17,691.22
  • GRANT
    Beak and Feather Disease Virus in wild avian populations in Australia
    3 Nov 2016 - 30 Jun 2020
    People funded by this grant:
    • Bennett A,
    • Berg M,
    • Walder K,
    • Martens JHM
    ESA - Holsworth Wildlife Research Endowment - 20 571 098 795 - $10,700.00
  • GRANT
    Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction
    6 Feb 2015 - 5 Feb 2018
    People funded by this grant:
    ARC Linkage - Projects - LP140100691 - $332,846.29
  • GRANT
    Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder
    1 Jan 2015 - 31 Dec 2017
    People funded by this grant:
    • Walder K,
    • Berk M,
    • Leboyer M,
    • Dean B
    NHMRC Project Grant - APP1078928 - $482,800.07
  • GRANT
    Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction
    31 Dec 2014 - 31 Dec 2017
    People funded by this grant:
    Zoos Victoria - $30,000.00
  • GRANT
    Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction
    31 Dec 2014 - 31 Dec 2017
    People funded by this grant:
    Victorian Department of Economic Development, Jobs, Transport and Resources - $50,000.00
  • CONTRACT RESEARCH
    Effects of encapsulation on bioavailability and distribution of orally administered milk lipid formulations
    4 Dec 2014 - 23 Nov 2015
    People funded by this grant:
    • Ken Walder
    Jogra Nominees Pty Ltd - The Trustee for THE SM WEST FAMILY TRUST - $52,899.00
  • CONTRACT RESEARCH
    Effects of encapsulation on bioavailability and distribution of orally administered milk lipid formulations
    4 Dec 2014 - 31 Dec 2016
    People funded by this grant:
    • Ken Walder
    WRS Therapeutics - $60,000.00
  • CONTRACT RESEARCH
    Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats
    1 Jan 2014 - 31 Dec 2014
    People funded by this grant:
    • Ken Walder
    Jogra Nominees Pty Ltd - The Trustee for THE SM WEST FAMILY TRUST - $13,454.54
  • INFRASTRUCTURE
    Fluorescent Cell Imager
    1 Jan 2014 - 30 Jun 2015
    People funded by this grant:
    • Ken Walder
    NHMRC - Equipment Grant (pre 2017) - GNT9000265 - $18,900.00
  • GRANT
    Delivery of MIRNA Using Genetically Modified Influenza Virus
    27 Aug 2012 - 26 Aug 2016
    People funded by this grant:
    Victorian International Research Scholarships - $60,000.00
  • GRANT
    The genetic basis of mercury sensitivity in pink disease survivors
    1 Jul 2012 - 30 Jun 2013
    People funded by this grant:
    • Austin D,
    • Walder K,
    • Gondalia S,
    • Shandley K,
    • Palombo E
    Coalition for SafeMinds - Research Grants - $53,646.76
  • GRANT
    The role of amyloid beta in insulin resistance
    1 Jan 2012 - 31 Dec 2014
    People funded by this grant:
    NHMRC Project Grant - APP1027226 - $415,322.14