MrsDemagi Herath

My research interests converge at the intersection of paediatric oncology, and epigenetics, with a specific focus on Osteosarcoma, which primarily affects young children and adolescents. Paediatric bone cancers present unique challenges due to their aggressive nature and the limited efficacy of current treatments. My passion for this field stems from a deep curiosity about the molecular mechanisms driving cancer initiation and progression in children and young adults. I am particularly drawn to the role of epigenetic modifications, specifically DNA methylation, and the role it plays in paediatric bone cancer. Epigenetic alterations can profoundly influence gene expression patterns, playing a crucial role in cancer initiation and development. Understanding these mechanisms at a molecular level could unveil novel biomarkers for early diagnosis and identify new therapeutic targets. Therefore, my research involves working with human mesenchymal stem cells and Osteosarcoma cell lines to study various DNA methylation patterns. In addition to my expertise in methylation-specific primer designing, microscopy, cell culture, stem cell isolation, expansion and differentiation, my research involves molecular biology techniques such PCR, qMS-PCR, and HRM.

Looking forward, I am committed to translating my research findings into clinical applications that improve outcomes for young patients battling bone cancer. By bridging the gaps between basic science and clinical practice, I aspire to contribute meaningful advancements to the field of paediatric oncology. Through interdisciplinary collaborations and innovative research methodologies, I am dedicated to making a lasting impact on the understanding and treatment of paediatric bone cancer.