Emeritus ProfessorLeigh Ackland
Emeritus Professor
Faculty of Science Engineering and Built Environment/Office of the Executive Dean Science, Engineering and Built Environment
Orcid identifier0000-0002-7474-6556 (opens in a new tab)
- Emeritus ProfessorFaculty of Science Engineering and Built Environment/Office of the Executive Dean Science, Engineering and Built Environment
RESEARCH INTERESTS
Identifcation of novel markers to assist in improved detection and treatment
of gastrointestinal neuroendocrine carcinomas and investigtion of drug
resistance.
Multifunctional and environmentally friendly corrosion inhibitor systems.
Epigenetic factors that underlie the pathology of type 2 diabetes during
pregnancy.
Molecular biology of zinc and copper in human diseases to understand zinc and
copper fluxes in cells and elucidation of inherited disorders in humans that
result in the production of trace element-deficient milk during lactation.
Mechanisms underlying the spread of breast and neuroendocrine cancers termed
"epithelial to mesenchymal transition" to understand why cancer cells
metastasise
How nanoliposome can be used to deliver omega-3 fatty acids to brain cells.
Development of remediation strategies for heavy metal-contaminated soils and
water.
Molecular basis of heavy metal tolerance in bacteria, fungi and plants.
Knowledge Areas
Cell and molecular biology and epigenetic processes in human disorders
including cancers and type 2 diabetes, the biology of trace elements and heavy
metals in bacteria, fungi, plants and animals
Projects
Currently funded projects
Molecular proflling of of Gastrointestinal Neuroendocrine Carcinomas". NHMRC
Project APP1102018, $1,393,082.86 in 2016 and Bourne Foundation funding
$000,000 in 2019.
Multifunctional and environmentally friendly corrosion inhibitor systems. ARC-
DP180101465. $392,952 in 2018
Epigenetic factors in Diabetes. Greater Green Triangle, University of
Melbourne $45,000 in 2016.With a team of clinicians, we are investigating
changers in histone methylation that occur in diabetes during pregnancy.
Past projects
Molecular biology of zinc and copper in human diseases to understand zinc and
copper fluxes in cells and elucidation of inherited disorders in humans that
result in the production of trace element-deficient milk during lactation.
Mechanisms underlying the spread of breast cancer cells
Using a novel human breast cancer line we study the mechanisms of breast
cancer metastasis termed "epithelial to mesenchymal transition".
Nanoliposomal delivery of DHA to human neuronal cells. ARC Discovery Project-
DP120101309. 2012-2014. $280,000.
Development of remediation strategies for heavy metal-contaminated soils and
water.
Molecular basis of heavy metal tolerance in plants where field trials of
selected plants were used to remediate cadmium-contaminated soils and to
establish the cellular mechanisms that enable plants to accumulate or resist
heavy metals.
of gastrointestinal neuroendocrine carcinomas and investigtion of drug
resistance.
Multifunctional and environmentally friendly corrosion inhibitor systems.
Epigenetic factors that underlie the pathology of type 2 diabetes during
pregnancy.
Molecular biology of zinc and copper in human diseases to understand zinc and
copper fluxes in cells and elucidation of inherited disorders in humans that
result in the production of trace element-deficient milk during lactation.
Mechanisms underlying the spread of breast and neuroendocrine cancers termed
"epithelial to mesenchymal transition" to understand why cancer cells
metastasise
How nanoliposome can be used to deliver omega-3 fatty acids to brain cells.
Development of remediation strategies for heavy metal-contaminated soils and
water.
Molecular basis of heavy metal tolerance in bacteria, fungi and plants.
Knowledge Areas
Cell and molecular biology and epigenetic processes in human disorders
including cancers and type 2 diabetes, the biology of trace elements and heavy
metals in bacteria, fungi, plants and animals
Projects
Currently funded projects
Molecular proflling of of Gastrointestinal Neuroendocrine Carcinomas". NHMRC
Project APP1102018, $1,393,082.86 in 2016 and Bourne Foundation funding
$000,000 in 2019.
Multifunctional and environmentally friendly corrosion inhibitor systems. ARC-
DP180101465. $392,952 in 2018
Epigenetic factors in Diabetes. Greater Green Triangle, University of
Melbourne $45,000 in 2016.With a team of clinicians, we are investigating
changers in histone methylation that occur in diabetes during pregnancy.
Past projects
Molecular biology of zinc and copper in human diseases to understand zinc and
copper fluxes in cells and elucidation of inherited disorders in humans that
result in the production of trace element-deficient milk during lactation.
Mechanisms underlying the spread of breast cancer cells
Using a novel human breast cancer line we study the mechanisms of breast
cancer metastasis termed "epithelial to mesenchymal transition".
Nanoliposomal delivery of DHA to human neuronal cells. ARC Discovery Project-
DP120101309. 2012-2014. $280,000.
Development of remediation strategies for heavy metal-contaminated soils and
water.
Molecular basis of heavy metal tolerance in plants where field trials of
selected plants were used to remediate cadmium-contaminated soils and to
establish the cellular mechanisms that enable plants to accumulate or resist
heavy metals.
GRANTS
- GRANTBacterial profiles in waterways associated with the Port Phillip Bay Ramsar site31 Jan 2026 - 31 Mar 2027People funded by this grant:
- Michalczyk A,
- Ackland L,
- Mondon J
- GRANTIdentification of cancer cell markers for early detection19 Sep 2019 - 31 Dec 2024People funded by this grant:
- Leigh Ackland
- GRANTTargeting site specific improvements of clinical trial operational processes.18 Mar 2019 - 2 Aug 2019People funded by this grant:
- Ackland L,
- Clatworthy SAS
- CONTRACT RESEARCHAmplification strategies in point-of-care electrochemical biosensors18 Jan 2017 - 31 Dec 2020People funded by this grant:
- Torriero A,
- Ackland L,
- Chatelier R
- GRANTWhole exome sequencing and methylation profiling of Neuroendocrine cancers from patients on the NABNEC trial8 Jul 2016 - 8 Jul 2018People funded by this grant:
- Khasraw M,
- Ashley D,
- Ackland L
- GRANTWhole exome sequencing and methylation profiling of Neuroendocrine cancers from patients on the NABNEC trial28 Jun 2016 - 30 Jun 2019People funded by this grant:
- Khasraw M,
- Ashley D,
- Ackland L
- GRANTNABNEC: A Randomised Phase II Study Of Nab-paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas1 Jan 2016 - 31 Dec 2020People funded by this grant:
- Khasraw M,
- Lipton L,
- Chantrill L,
- Hofman M,
- Ackland L
- CONTRACT RESEARCHCharacterisation of magnetic or other beads modified with proteins12 Oct 2015 - 18 Dec 2015People funded by this grant:
- Ackland L,
- Torriero A
- FELLOWSHIPMetastasis in breast cancer cells1 Nov 2014 - 30 Jun 2015People funded by this grant:
- Ackland L,
- Ahire V
- INFRASTRUCTUREOrion Conductivity Probes17 Oct 2014 - 30 Jun 2015People funded by this grant:
- Leigh Ackland
- CONTRACT RESEARCHA Feasibility Study Of NAB-Paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas (NABNEC)1 Sep 2014 - 1 Sep 2017People funded by this grant:
- Khasraw M,
- Ackland L
- CONTRACT RESEARCHPreliminary screening of a saltwater lake sample to identify potentially useful pigment molecules30 Jun 2014 - 31 Aug 2014People funded by this grant:
- Torriero A,
- Hudek L,
- Ackland L
- CONTRACT RESEARCHOptimisation of the carotenoid biosynthesis from Haematococcus pluvialis23 Jun 2014 - 31 Dec 2014People funded by this grant:
- Torriero A,
- Ackland L
- GRANTNanoliposomal delivery of DHA to neuronal cells1 Jan 2012 - 31 Dec 2014People funded by this grant:
- Ackland L,
- Sinclair A,
- Suphioglu C,
- Singh H
- GRANTEstablishment of a Biosensor Facility at the Centre for Cellular and Molecular Biology (CCMB), Deakin University, Burwood.1 Jan 2010 - 31 Dec 2011People funded by this grant:
- Suphioglu C,
- Ackland L,
- Fontaine SL,
- Mercer J
- GRANTThe contribution of host caveolin-1 to breast cancer metastasis1 Jan 2010 - 31 Dec 2012People funded by this grant:
- Anderson R,
- Ackland L
- GRANTTriggering the dormant capacity of fish to make omega 3 fatty acids1 Jan 2010 - 31 Dec 2014People funded by this grant:
- Turchini G,
- Sinclair A,
- Ackland L
- GRANTEstablishment of a Flow Cytometry Facility at the Centre for Cellular and Molecular Biology, Deakin University30 Oct 2008 - 31 Dec 2010People funded by this grant:
- Suphioglu C,
- Ackland L,
- Fontaine SL,
- Mercer J
- GRANTMolecular Eco-toxicology for diagnosis of priority pollutants in soil18 Oct 2007 - 20 Oct 2011People funded by this grant:
- Ackland L,
- Song Y
- GRANTCopper transport in lactation10 Mar 2004 - 31 Dec 2008People funded by this grant:
- Mercer J,
- Ackland L,
- Linder MC