ProfessorSean McGee
Professor, Medical Biology
Faculty of Health/School of Medicine/Institute for Mental and Physical Health and Clinical Translation
Orcid identifier0000-0001-6953-106X (opens in a new tab)
- Professor, Medical BiologyFaculty of Health/School of Medicine/Institute for Mental and Physical Health and Clinical Translation
- +61 3 522 72519 (Work)
- Geelong Waurn Ponds Campus, 75 Pigdons Road, Waurn Ponds, Victoria 3216
RESEARCH INTERESTS
Chronic over-nutrition is driving an epidemic of chronic diseases that includes obesity and type 2 diabetes, cardiovascular disease and cancer.
Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.
Knowledge Areas
Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cardiac metabolism, cancer metabolism
Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.
Knowledge Areas
Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cardiac metabolism, cancer metabolism
GRANTS
- GRANTFoundations of a Resilient Microbiome: The Barwon Infant Study2 Mar 2026 - 1 Mar 2027People funded by this grant:
- Vuillermin P,
- Mcgee S,
- Sominsky L,
- O'Hely M,
- Dawson S
- GRANTVCCC Study Coordinator Internship - Peter MacCallum Cancer Centre9 Feb 2026 - 13 Nov 2026People funded by this grant:
- Mcgee S,
- Mehrabifar A
- GRANTBiomarkers of negative symptoms, cognitive impairment and metabolic abnormalities in schizophrenia1 Oct 2022 - 1 Apr 2024People funded by this grant:
- Yung A,
- Mcgee S,
- Sominsky L,
- Walder K,
- Pasco J
- GRANTFasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance1 Jun 2021 - 31 May 2022People funded by this grant:
- Shaw C,
- Bruce C,
- Howlett K,
- Mcgee S,
- Kowalski G
- CONTRACT RESEARCHNew therapies for obesity-induced heart disease.1 Jun 2020 - 31 Dec 2020People funded by this grant:
- Sean Mcgee
- GRANTA novel approach to target beta-cells to enhance survival and function1 Jan 2020 - 31 Dec 2020People funded by this grant:
- Aston-Mourney K,
- Shigdar S,
- Mcgee S
- GRANTRole of protein kinase D in adiposity and the regulation of body weight1 Jan 2019 - 31 Dec 2021People funded by this grant:
- Mcgee S,
- Andrews Z,
- James D
- GRANTDevelopment of new exercise mimetics for better treatment of metabolic and heart diseases6 Dec 2018 - 6 Jun 2020People funded by this grant:
- Sean Mcgee
- GRANTDevelopment of new exercise mimetics for better treatment of metabolic and heart diseases6 Dec 2018 - 6 Jun 2020People funded by this grant:
- Sean Mcgee
- GRANTThe role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy1 Jan 2017 - 31 Dec 2017People funded by this grant:
- Mcgee S,
- Bruce C
- GRANTIdentifying the role of altered mitochondrial metabolism in malignant rhabdoid tumours and evaluating potential epigenetic therapies1 Jan 2016 - 31 Dec 2016People funded by this grant:
- Ashley D,
- Mcgee S,
- Cain J
- GRANTThe role of GAPDH acetylation in the regulation of liver metabolism1 Jan 2016 - 31 Dec 2016People funded by this grant:
- Sean Mcgee
- GRANTTargeting class IIa histone deacetylases to impair breast cancer cell metabolism and survival9 Jan 2015 - 31 Dec 2016People funded by this grant:
- Sean Mcgee
- GRANTHDAC Inhibition as a Potential Therapy for Preventing the Progression of Type 2 Diabetes1 Jan 2015 - 31 Jan 2016People funded by this grant:
- Aston-Mourney K,
- Mcgee S
- GRANTTargeting protein kinase D to treat diabetic cardiomyopathy1 Jan 2015 - 31 Dec 2015People funded by this grant:
- Mcgee S,
- Vernados K
- GRANTTransforming fat to increase energy expenditure1 Jan 2013 - 31 Dec 2013People funded by this grant:
- Sean Mcgee
- FELLOWSHIPTargeting the class IIa histone deacetylases in metabolic disease1 Jan 2012 - 31 Dec 2015People funded by this grant:
- Sean Mcgee
- GRANTThe role of amyloid beta in insulin resistance1 Jan 2012 - 31 Dec 2014People funded by this grant:
- Mcgee S,
- Walder K,
- Hargreaves M
- GRANTUnderstanding the role of class IIa histone deacetylases in metabolic disease1 Jan 2012 - 31 Dec 2014People funded by this grant:
- Mcgee S,
- Walder K
- GRANTActivation of HSP72 in skeletal muscle as a therapeutic target for obesity1 Jan 2011 - 31 Dec 2013People funded by this grant:
- Febbraio M,
- Bruce C,
- Mcgee S,
- Hargreaves M
- GRANTMechanistically linking type 2 diabetes and Alzheimer's disease28 Sep 2010 - 31 Dec 2012People funded by this grant:
- Sean Mcgee